Our group aims to understand how genomes are folded in different cellular contexts, how cells re-fold their genomes, and how this folding facilitates various biological functions of DNA. We are a “dry” lab – we do not do experiments and rely on purely theoretical approaches. First, we use methods of computational biology, i.e. we analyze massive biological datasets and develop new methods and software for data analysis. Second, we model genome folding using physical models. With these models, we test various hypotheses on the mechanism of genome folding against diverse types of experimental data.