Mass spectrometry (MS) has emerged as a core analytical technique in protein chemistry. Driven by the rapid development of instrumentation, analysis methods and computing tools, MS based proteomics is at the forefront of techniques in modern life science research and nowadays allows the study of nearly complete proteomes.In the Mechtler lab, we are interested in developing new methods to increase sensitivity in protein identification, accuracy and precision of protein quantification as well as for the detection of posttranslational modifications. Additionally, we establish methods in the field of protein cross-linking mass spectrometry and single cell proteomics. Another focus is the development of new algorithms for MS data interpretation and bioinformatic analysis.To achieve these goals, we frequently collaborate with chromatography and MS companies to test newest column materials, instrumentation and software.